Mega Man 10 takes place during the 21st century ('20XX') and continues the adventures of the android hero Mega Man. An illness known as 'Roboenza' suddenly begins infecting robots all over the world, causing them to malfunction and hamper human life. Mega Man's sister Roll becomes one of the disease's victims. A month following the outbreak, many of the infected robots go berserk and attempt to take over the world. Light, claiming that he was building a machine making medicine to cure the disease before one of the infected robots stole it. Mega Man decides to help retrieve the machine and soon runs into his brother Proto Man, who quickly joins him. Meanwhile, Mega Man's rival Bass sets out on his own to challenge these new robots. Mega Man halfway finishes his journey when Dr. Wily completes a prototype antidote, which is given to Roll.Īfter all eight 'Robot Masters' (which appear to be old models) – Sheep Man, Commando Man, Blade Man, Strike Man, Solar Man, Chill Man, Nitro Man and Pump Man – are defeated, Mega Man himself appears to have contracted Roboenza.

Wily appears on television and reveals that he created the virus, and only developed a cure so he could bribe all the infected robots into coming to work for him. Roll gives Mega Man her medicine, saying she had saved it in case 'a really sick robot was brought in.' However, if she swallows it herself, all will be lost because Dr. Light created her with no Variable Weapon System. So, Mega Man reluctantly takes Roll's dose so that he can go defeat Wily and bring back enough medicine for everyone else. During the raid on Wily's fortress, Proto Man comes down with Roboenza as well, only to be saved by Mega Man, who acquired an extra sample of the cure.

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